Anti-CHMP4B Antibody

Rs. 45,619.00
SKU stj29539

General Information

Product name Anti-CHMP4B Antibody
Short Description Rabbit polyclonal to CHMP4B
Description This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CHMP4B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human CHMP4B (NP_789782.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 24.9 kDa
Database Links
Alternative Names CHMP4BCharged multivesicular body protein 4b antibodyChromatin-modifying protein 4b antibodyCHMP4b antibodySNF7 homolog associated with Alix 1 antibodySNF7-2 antibodyhSnf7-2 antibodyVacuolar protein sorting-associated protein 32-2 antibodyVps32-2 antibodyhVps32-2CHMP4B antibodyC20orf178 antibodySHAX1
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs, MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids, The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes, ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released , Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
Cellular Localization Cytoplasm, cytosol.
Tissue Specificity Widely expressed, expressed at higher level in heart and skeletal muscle, also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.
Swiss-Prot Key

 

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