Anti-CHP2 antibody

Rs. 50,211.00
SKU stj92280

General Information

Product name Anti-CHP2 antibody
Short Description
Description Rabbit polyclonal to CHP2.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-CHP2 antibody
Immunogen Synthesized peptide derived from human CHP2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 22 kDa
Database Links
Alternative Names Calcineurin B homologous protein 2 antibody
Hepatocellular carcinoma-associated antigen 520 antibody
HCA520 antibody
Function Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Cellular Localization Nucleus Cytoplasm Cell membrane. Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane . Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm.
Tissue Specificity Expressed in malignantly transformed cells but not detected in normal tissues.
Swiss-Prot Key

 

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