Anti-CIC Antibody

Rs. 45,619.00
SKU stj117603

General Information

Product name Anti-CIC Antibody
Short Description Rabbit polyclonal to CIC
Description The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Protein capicua homolog
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 163.8 kDa
Database Links
Alternative Names CICProtein capicua homologCIC antibodyKIAA0306
Function Transcriptional repressor which plays a role in development of the central nervous system (CNS), In concert with ATXN1 and ATXN1L, involved in brain development.
Cellular Localization Nucleus
Tissue Specificity Expressed in fetal brain.
Swiss-Prot Key

 

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