Anti-CIDEC Antibody

Rs. 45,619.00
SKU stj27998

General Information

Product name Anti-CIDEC Antibody
Short Description Rabbit polyclonal to CIDEC
Description This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CIDEC Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-238 of human CIDEC (NP_001186481.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 26.8 kDa
Database Links
Alternative Names CIDECCell death activator CIDE-3 antibodyCell death-inducing DFFA-like effector protein C antibodyFat-specific protein FSP27 homologCIDEC antibodyFSP27
Function Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage, At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets, The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair, Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1, May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH, When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment, As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear, May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
Cellular Localization Nucleus, Endoplasmic reticulum, Lipid droplet.
Tissue Specificity Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
Swiss-Prot Key

 

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