Anti-CILP Antibody

Rs. 68,577.00
SKU stj70969

General Information

Product name Anti-CILP Antibody
Short Description Goat polyclonal to CILP
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-CILP Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 132.6 kDa
Database Links
Alternative Names CILPCartilage intermediate layer protein 1 antibodyCILP-1 antibodyCartilage intermediate-layer proteinCILP antibodyUNQ602/PRO1188
Function Probably plays a role in cartilage scaffolding, May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions, Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation, May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1, Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage,
Cellular Localization Secreted, extracellular space, extracellular matrix
Tissue Specificity Specifically expressed in cartilage, localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions, specifically and highly expressed in intervertebral disk tissue, expression increases with aging in hip articular cartilage, overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (cppd), expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses,
Swiss-Prot Key

 

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