Anti-CKR-4 antibody

Rs. 50,211.00
SKU stj92300

General Information

Product name Anti-CKR-4 antibody
Short Description
Description Rabbit polyclonal to CKR-4.
Applications IF,ELISA
Dilution range IF 1:200-1:1000ELISA 1:40000
Protein Name Anti-CKR-4 antibody
Immunogen Synthesized peptide derived from human CKR-4
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 41 kDa
Database Links
Alternative Names C-C chemokine receptor type 4 antibody
C-C CKR-4 antibody
CC-CKR-4 antibody
CCR-4 antibody
K5-5 antibody
CD antigen CD194 antibody
CMKBR4 antibody
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Cellular Localization Cell membrane. Multi-pass membrane protein.
Tissue Specificity Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Swiss-Prot Key

 

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