Anti-Claudin-1 antibody

Rs. 50,211.00
SKU stj92308

General Information

Product name Anti-Claudin-1 antibody
Short Description
Description Rabbit polyclonal to Claudin-1.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:20000
Protein Name Anti-Claudin-1 antibody
Immunogen Synthesized peptide derived from human Claudin-1 around the non-phosphorylation site of Y210.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 30 kDa
Database Links
Alternative Names Claudin-1 antibody
Senescence-associated epithelial membrane protein antibody
CLD1 antibody
SEMP1 antibody
UNQ481/PRO944 antibody
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions . (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes . Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell . Acts as a receptor for dengue virus .
Cellular Localization Cell junction, tight junction Cell membrane Basolateral cell membrane. Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Tissue Specificity Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed