Anti-CLC Antibody

Rs. 45,619.00
SKU stj117459

General Information

Product name Anti-CLC Antibody
Short Description Rabbit polyclonal to CLC
Description Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Galectin-10Gal-10Charcot-Leyden crystal proteinCLCEosinophil lysophospholipaseLysolecithin acylhydrolase
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human CLC (NP_001819.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 16.5 kDa
Database Links
Alternative Names CLCGalectin-10 antibodyGal-10 antibodyCharcot-Leyden crystal protein antibodyCLC antibodyEosinophil lysophospholipase antibodyLysolecithin acylhydrolaseCLC antibodyLGALS10 antibodyLGALS10A
Function Regulates immune responses through the recognition of cell-surface glycans, Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
Cellular Localization Cytoplasm, cytosol.
Tissue Specificity Expressed abundantly in the bone marrow, expressed exclusively by eosinophils and basophils, not detected in monocytes and neutrophils, expressed in cd25-positive regulatory t-cells (treg) (at protein level), found in intestinal tissue from patients with celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level), found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level).
Swiss-Prot Key

 

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