Anti-CLCA1 Antibody

Rs. 45,619.00
SKU stj117235

General Information

Product name Anti-CLCA1 Antibody
Short Description Rabbit polyclonal to CLCA1
Description This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Calcium-activated chloride channel regulator 1
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-150 of human CLCA1 (NP_001276.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 100.2 kDa
Database Links
Alternative Names CLCA1Calcium-activated chloride channel regulator 1 CLCA1 antibodyCACC1
Function May be involved in mediating calcium-activated chloride conductance, May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR, May be involved in the regulation of mucus production and/or secretion by goblet cells, Involved in the regulation of tissue inflammation in the innate immune response, May play a role as a tumor suppressor, Induces MUC5AC.
Cellular Localization Secreted, extracellular space.
Tissue Specificity Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix, weakly expressed in uterus, testis and kidney, expressed in the airways epithelium of both asthmatic and healthy patients, expressed in the bronchial epithelium, especially in mucus-producing goblet cells, expressed in normal turbinate mucosa and nasal polyp, expressed in.
Swiss-Prot Key

 

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