Anti-CLDN11 Antibody

Rs. 45,619.00
SKU stj23156

General Information

Product name Anti-CLDN11 Antibody
Short Description Rabbit polyclonal to CLDN11
Description This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:20 - 1:50
Protein Name Anti-CLDN11 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-207 of human CLDN11 (NP_005593.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 22 kDa
Database Links
Alternative Names CLDN11Claudin-11 antibodyOligodendrocyte-specific proteinCLDN11 antibodyOSP antibodyOTM
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Cellular Localization Cell junction, tight junction, Cell membrane
Tissue Specificity
Swiss-Prot Key

 

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