Anti-Cleaved-Kininogen-1 HC (K380) antibody

Rs. 50,211.00
SKU stj90095

General Information

Product name Anti-Cleaved-Kininogen-1 HC (K380) antibody
Short Description
Description Rabbit polyclonal to Cleaved-Kininogen-1 HC (K380).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Cleaved-Kininogen-1 HC (K380) antibody
Immunogen Synthesized peptide derived from human Kininogen-1 HC
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 41 kDa
Database Links
Alternative Names Cleaved-Kininogen-1 HC (K380)
Kininogen-1 antibody
Alpha-2-thiol proteinase inhibitor antibody
Fitzgerald factor antibody
High molecular weight kininogen antibody
HMWK antibody
Williams-Fitzgerald-Flaujeac factor antibody
Kininogen-1 heavy chain antibody
T-kinin antibody
Ile-Ser-Bradykinin antibody
Bradykinin antibody
Kallidin I antibody
Lysyl-bradykinin antibody
Kallidin II antibody
Kininogen-1 light chain antibody
Low molecular weight growth-promoting factor antibody
BDK antibody
KNG antibody
Function (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Cellular Localization Secreted, extracellular space.
Tissue Specificity Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
Swiss-Prot Key

 

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