Anti-Cleaved-Notch 2 (A1734) antibody

Rs. 50,211.00
SKU stj90067

General Information

Product name Anti-Cleaved-Notch 2 (A1734) antibody
Short Description
Description Rabbit polyclonal to Cleaved-Notch 2 (A1734).
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Cleaved-Notch 2 (A1734) antibody
Immunogen Synthesized peptide derived from human Notch 2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 79 kDa
Database Links
Alternative Names Cleaved-Notch 2 (A1734)
Neurogenic locus notch homolog protein 2 antibody
Notch 2 antibody
hN2 antibody
Notch 2 extracellular truncation antibody
N2ECD antibody
Notch 2 intracellular domain antibody
N2ICD antibody
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs . Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells .
Cellular Localization Notch 2 extracellular truncation: Cell membrane Notch 2 intracellular domain: Nucleus Cytoplasm. Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by C8orf4 .
Tissue Specificity Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
Swiss-Prot Key

 

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