Anti-CLEC4M Antibody

Rs. 45,619.00
SKU stj116481

General Information

Product name Anti-CLEC4M Antibody
Short Description Rabbit polyclonal to CLEC4M
Description This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name C-type lectin domain family 4 member MCD209 antigen-like protein 1DC-SIGN-related proteinDC-SIGNRDendritic cell-specific ICAM-3-grabbing non-integrin 2DC-SIGN2Liver/lymph node-specific ICAM-3-grabbing non-integrinL-SIGNCD antigen CD299
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 280-399 of human CLEC4M (NP_055072.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.4 kDa
Database Links
Alternative Names CLEC4MC-type lectin domain family 4 member M antibodyCD209 antigen-like protein 1 antibodyDC-SIGN-related protein antibodyDC-SIGNR antibodyDendritic cell-specific ICAM-3-grabbing non-integrin 2 antibodyDC-SIGN2 antibodyLiver/lymph node-specific ICAM-3-grabbing non-integrin antibodyL-SIGN antibodyCD antigen CD299CLEC4M antibodyCD209L antibodyCD209L1 antibodyCD299
Function Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver, May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments, Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Cellular Localization Cell membrane
Tissue Specificity Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node, found in placental endothelium but not in macrophages, expressed in type ii alveolar cells and lung endothelial cells.
Swiss-Prot Key

 

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