Anti-CLIC4 Antibody

Rs. 45,619.00
SKU stj29168

General Information

Product name Anti-CLIC4 Antibody
Short Description Rabbit polyclonal to CLIC4
Description Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name Anti-CLIC4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human CLIC4 (NP_039234.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 28.8 kDa
Database Links
Alternative Names CLIC4Chloride intracellular channel protein 4 antibodyIntracellular chloride ion channel protein p64H1CLIC4
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions, Channel activity depends on the pH, Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, Promotes cell-surface expression of HRH3, Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis, Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasmic vesicle membrane, Mitochondrion, Cell junction.
Tissue Specificity Detected in epithelial cells from colon, esophagus and kidney (at protein level), expression is prominent in heart, kidney, placenta and skeletal muscle.
Swiss-Prot Key

 

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