Anti-CLU Antibody

Rs. 68,577.00
SKU stj72845

General Information

Product name Anti-CLU Antibody
Short Description Goat polyclonal to CLU
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-CLU Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 52.5 kDa
Database Links
Alternative Names CLUClusterin antibodyAging-associated gene 4 protein antibodyApolipoprotein J antibodyApo-J antibodyComplement cytolysis inhibitor antibodyCLI antibodyComplement-associated protein SP-40,40 antibodyKu70-binding protein 1 antibodyNA1/NA2 antibodyTestosterone-repressed prostate message 2 antibodyTRPM-2CLU antibodyAPOJ antibodyCLI antibodyKUB1 antibodyAAG4
Function Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins, Prevents stress-induced aggregation of blood plasma proteins, Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro), Does not require ATP, Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70, Does not refold proteins by itself, Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation, Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement, Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins, Promotes proteasomal degradation of COMMD1 and IKBKB, Modulates NF-kappa-B transcriptional activity, Nuclear isoforms promote apoptosis, Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis, Plays a role in the regulation of cell proliferation,
Cellular Localization Secreted, Cytoplasmic side, Cytoplasm, cytosol, Microsome, Endoplasmic reticulum, Cytoplasmic vesicle, secretory vesicle, chromaffin granule,
Tissue Specificity Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa, detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the auerbach plexus (at protein level), ubiquitous, detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung,
Swiss-Prot Key

 

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