Anti-Clusterin Antibody

Rs. 68,577.00
SKU stj72729

General Information

Product name Anti-Clusterin Antibody
Short Description Goat polyclonal to Clusterin / ApoJ (mouse, aa312-325)
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-Clusterin Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 51.7 kDa
Database Links
Alternative Names Anti-Clusterin / ApoJ (mouse, aa312-325) Antibody
Function Functions as extracellular chaperone that prevents aggregation of nonnative proteins, Prevents stress-induced aggregation of blood plasma proteins, Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro), Does not require ATP, Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70, Does not refold proteins by itself, Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation, When secreted, protects cells against apoptosis and against cytolysis by complement, Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins, Promotes proteasomal degradation of COMMD1 and IKBKB, Modulates NF-kappa-B transcriptional activity, Promotes apoptosis when in the nucleus, Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm, Plays a role in the regulation of cell proliferation (By similarity),
Cellular Localization Secreted,
Tissue Specificity Most abundant in stomach, liver, brain, and testis, with intermediate levels in heart, ovary and kidney
Swiss-Prot Key

 

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