Anti-CNGA3 Antibody

Rs. 45,619.00
SKU stj23180

General Information

Product name Anti-CNGA3 Antibody
Short Description Rabbit polyclonal to CNGA3
Description This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CNGA3 Antibody
Immunogen Recombinant protein of human CNGA3
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 78.8 kDa
Database Links
Alternative Names CNGA3Cyclic nucleotide-gated cation channel alpha-3 antibodyCone photoreceptor cGMP-gated channel subunit alpha antibodyCyclic nucleotide-gated channel alpha-3 antibodyCNG channel alpha-3 antibodyCNG-3 antibodyCNG3CNGA3 antibodyCNCG3
Function Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger, This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors, Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity), Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Cellular Localization Membrane
Tissue Specificity Prominently expressed in retina
Swiss-Prot Key

 

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