Anti-LECT1 Antibody

Rs. 45,619.00
SKU stj28727

General Information

Product name Anti-LECT1 Antibody
Short Description Rabbit polyclonal to CNMD
Description This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-LECT1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human LECT1 (NP_008946.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.1 kDa
Database Links
Alternative Names CNMDLeukocyte cell-derived chemotaxin 1 antibodyChondromodulinCNMD antibodyCHMI antibodyLECT1 antibodyMYETS1
Function Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells, May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development, Inhibits in vitro tube formation and mobilization of endothelial cells, Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Cellular Localization Chondromodulin-1: Secreted, extracellular space, extracellular matrix, Chondrosurfactant protein: Endomembrane system
Tissue Specificity Detected in cartilage and cardiac valves (at protein level), detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level), expression is decreased cardiac valves of patients with valvular heart disease (at protein level), weakly expressed in chondrosarcoma.
Swiss-Prot Key

 

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