Anti-CNR2 Antibody

Rs. 45,619.00
SKU stj116157

General Information

Product name Anti-CNR2 Antibody
Short Description Rabbit polyclonal to CNR2
Description The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.
Applications WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Cannabinoid receptor 2CB-2CB2hCB2CX5
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CNR2 (NP_001832.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39.7 kDa
Database Links
Alternative Names CNR2Cannabinoid receptor 2 antibodyCB-2 antibodyCB2 antibodyhCB2 antibodyCX5CNR2 antibodyCB2A antibodyCB2B
Function Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase, May function in inflammatory response, nociceptive transmission and bone homeostasis.
Cellular Localization Cell membrane
Tissue Specificity Preferentially expressed in cells of the immune system with higher expression in b-cells and nk cells (at protein level), expressed in skin in suprabasal layers and hair follicles (at protein level), highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus, pubmed:14657172 could not detect expression in normal brain, expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level), two isoforms are produced by alternative promoter usage and differ only in the 5' utr: isoform cb2a is observed predominantly in testis with some expression in brain, while isoform cb2b is predominant in spleen and leukocytes.
Swiss-Prot Key

 

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