Anti-COL18A1 Antibody

Rs. 45,619.00
SKU stj23189

General Information

Product name Anti-COL18A1 Antibody
Short Description Rabbit polyclonal to COL18A1
Description This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-COL18A1 Antibody
Immunogen A synthetic peptide of human COL18A1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 178.2 kDa
Database Links
Alternative Names COL18A1Collagen alpha-1(XVIII antibodychain COL18A1
Function Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
Cellular Localization Secreted, extracellular space, extracellular matrix
Tissue Specificity Present in multiple organs with highest levels in liver, lung and kidney
Swiss-Prot Key

 

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