General Information
Product name | Anti-COL4A2 antibody |
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Short Description | |
Description | Rabbit polyclonal to COL4A2. |
Applications | WB,IHC,IF,ELISA |
Dilution range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
Protein Name | Anti-COL4A2 antibody |
Immunogen | Synthesized peptide derived from human COL4A2 |
Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
Type of Usage | For Research Use Only (RUO). |
Product Properties
Host | Rabbit |
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Clonality | Polyclonal |
Reactivity | Mouse |
Conjugation | Unconjugated |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Isotype | IgG |
Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
Gene ID | |
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Gene Symbol | |
Molecular Weight | 150 kDa |
Database Links | |
Alternative Names | Collagen alpha-2 antibody IV chain antibody Canstatin antibody |
Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. |
Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. |
Tissue Specificity | |
Swiss-Prot Key |