Anti-COL4A3 Antibody

Rs. 68,577.00
SKU stj73325

General Information

Product name Anti-COL4A3 Antibody
Short Description Goat polyclonal to COL4A3
Description
Applications ELISA, IHC
Dilution range
Protein Name Anti-COL4A3 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 161.8 kDa
Database Links
Alternative Names COL4A3Collagen alpha-3(IV antibodychain antibodyGoodpasture antigenCOL4A3
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen
Cellular Localization Secreted, extracellular space, extracellular matrix, basement membrane,
Tissue Specificity Alpha 3 and alpha 4 type iv collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung, pubmed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type iv collagens in kidney, but pubmed:7523402 reports that in kidney levels of alpha 3 type iv collagen are significantly lower than those of alpha 4 type iv collagen, according to pubmed:8083201, alpha 3 type iv collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver, according to pubmed:7523402, alpha 3 type iv collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin, isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3, isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells,
Swiss-Prot Key

 

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