Anti-COMP Antibody

Rs. 45,619.00
SKU stj28375

General Information

Product name Anti-COMP Antibody
Short Description Rabbit polyclonal to COMP
Description The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:10 - 1:100
Protein Name Anti-COMP Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP (NP_000086.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 82.9 kDa
Database Links
Alternative Names COMPCartilage oligomeric matrix protein antibodyCOMP antibodyThrombospondin-5 antibodyTSP5COMP
Function May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin, Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors, Could play a role in the pathogenesis of osteoarthritis, Potent suppressor of apoptosis in both primary chondrocytes and transformed cells, Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP), Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli, Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
Cellular Localization Secreted, extracellular space, extracellular matrix
Tissue Specificity Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels, increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Swiss-Prot Key

 

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