Anti-COPS2 Antibody

Rs. 68,577.00
SKU stj70367

General Information

Product name Anti-COPS2 Antibody
Short Description Goat polyclonal to COPS2
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-COPS2 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 51.6 kDa
Database Links
Alternative Names COPS2COP9 signalosome complex subunit 2 antibodySGN2 antibodySignalosome subunit 2 antibodyAlien homolog antibodyJAB1-containing signalosome subunit 2 antibodyThyroid receptor-interacting protein 15 antibodyTR-interacting protein 15 antibodyTRIP-15COPS2 antibodyCSN2 antibodyTRIP15
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes, The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2, The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases, CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively, Involved in early stage of neuronal differentiation via its interaction with NIF3L1,
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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