Anti-COPS3 Antibody

Rs. 45,619.00
SKU stj29097

General Information

Product name Anti-COPS3 Antibody
Short Description Rabbit polyclonal to COPS3
Description The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-COPS3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 194-423 of human COPS3 (NP_003644.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 47.9 kDa
Database Links
Alternative Names COPS3COP9 signalosome complex subunit 3 antibodySGN3 antibodySignalosome subunit 3 antibodyJAB1-containing signalosome subunit 3COPS3 antibodyCSN3
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes, The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2, The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases, CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Localization Cytoplasm
Tissue Specificity Widely expressed, expressed at high level in heart and skeletal muscle.
Swiss-Prot Key

 

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