Anti-COPS5 Antibody

Rs. 45,619.00
SKU stj23200

General Information

Product name Anti-COPS5 Antibody
Short Description Rabbit polyclonal to COPS5
Description The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-COPS5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human COPS5 (NP_006828.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37.6 kDa
Database Links
Alternative Names COPS5COP9 signalosome complex subunit 5 antibodySGN5 antibodySignalosome subunit 5COPS5 antibodyCSN5 antibodyJAB1
Function Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes, The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2, The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases, CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively, In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins, It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex, Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex, Promotes the proteasomal degradation of BRSK2.
Cellular Localization Cytoplasm, cytosol
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed