Anti-COPS8 Antibody

Rs. 45,619.00
SKU stj114618

General Information

Product name Anti-COPS8 Antibody
Short Description Rabbit polyclonal to COPS8
Description The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name COP9 signalosome complex subunit 8SGN8Signalosome subunit 8COP9 homologhCOP9JAB1-containing signalosome subunit 8
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human COPS8 (NP_006701.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 23.2 kDa
Database Links
Alternative Names COPS8COP9 signalosome complex subunit 8 antibodySGN8 antibodySignalosome subunit 8 antibodyCOP9 homolog antibodyhCOP9 antibodyJAB1-containing signalosome subunit 8COPS8 antibodyCSN8
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes, The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2, The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases, CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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