Anti-Cortactin antibody

Rs. 50,211.00
SKU stj92429

General Information

Product name Anti-Cortactin antibody
Short Description
Description Rabbit polyclonal to Cortactin.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Cortactin antibody
Immunogen Synthesized peptide derived from human Cortactin around the non-phosphorylation site of Y466.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 85/68/80 kDa
Database Links
Alternative Names Src substrate cortactin antibody
Amplaxin antibody
Oncogene EMS1 antibody
EMS1 antibody
Function Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density . Plays a role in the invasiveness of cancer cells, and the formation of metastases . Plays a role in focal adhesion assembly and turnover . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane . Plays a role in receptor-mediated endocytosis via clathrin-coated pits . Required for stabilization of KCNH1 channels at the cell membrane .
Cellular Localization Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, ruffle. Cell projection, dendrite Cell projection Cell membrane Cell projection, podosome Cell junction Cell junction, focal adhesion Membrane, clathrin-coated pit Cell projection, dendritic spine Cytoplasm, cell cortex. Colocalizes transiently with PTK2/FAK1 at focal adhesions . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers . In the presence of CTTNBP2, localizes at the cell cortex . In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones .
Tissue Specificity
Swiss-Prot Key

 

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