Anti-COX10 Antibody

Rs. 45,619.00
SKU stj29685

General Information

Product name Anti-COX10 Antibody
Short Description Rabbit polyclonal to COX10
Description Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-COX10 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human COX10 (NP_001294.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.9 kDa
Database Links
Alternative Names COX10Protoheme IX farnesyltransferase antibodymitochondrial COX10
Function Converts protoheme IX and farnesyl diphosphate to heme O.
Cellular Localization Mitochondrion membrane
Tissue Specificity
Swiss-Prot Key

 

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