Anti-CRACR2A Antibody

Rs. 45,619.00
SKU stj115779

General Information

Product name Anti-CRACR2A Antibody
Short Description Rabbit polyclonal to CRACR2A
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name EF-hand calcium-binding domain-containing protein 4BCalcium release-activated calcium channel regulator 2ACRAC channel regulator 2ACalcium release-activated channel regulator 2A
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CRACR2A (NP_001138430.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.6 kDa
Database Links
Alternative Names CRACR2AEF-hand calcium-binding domain-containing protein 4B antibodyCalcium release-activated calcium channel regulator 2A antibodyCRAC channel regulator 2A antibodyCalcium release-activated channel regulator 2ACRACR2A antibodyEFCAB4B
Function Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation, Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration, It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1, Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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