Anti-CRADD Antibody

Rs. 45,619.00
SKU stj23217

General Information

Product name Anti-CRADD Antibody
Short Description Rabbit polyclonal to CRADD
Description This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CRADD Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human CRADD (NP_003796.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 22.7 kDa
Database Links
Alternative Names CRADDDeath domain-containing protein CRADD antibodyCaspase and RIP adapter with death domain antibodyRIP-associated protein with a death domainCRADD antibodyRAIDD
Function Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP, In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex
Cellular Localization Cytoplasm
Tissue Specificity Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney
Swiss-Prot Key

 

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