Anti-CREB-2 antibody

Rs. 50,211.00
SKU stj92467

General Information

Product name Anti-CREB-2 antibody
Short Description
Description Rabbit polyclonal to CREB-2.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-CREB-2 antibody
Immunogen Synthesized peptide derived from human CREB-2 around the non-phosphorylation site of S219.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 38 kDa
Database Links
Alternative Names Cyclic AMP-dependent transcription factor ATF-4 antibody
cAMP-dependent transcription factor ATF-4 antibody
Activating transcription factor 4 antibody
Cyclic AMP-responsive element-binding protein 2 antibody
cAMP-responsive element-binding protein 2 antibody
DNA-binding protein TAXREB67 antibody
Tax-responsive enhancer element-binding protein 67 antibody
TaxREB67 antibody
CREB2 antibody
TXREB antibody
Function Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production . It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors .
Cellular Localization Cytoplasm Cell membrane Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes . Colocalizes with NEK6 at the centrosome .
Tissue Specificity
Swiss-Prot Key

 

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