Anti-CREB3L2 antibody

Rs. 50,211.00
SKU stj92469

General Information

Product name Anti-CREB3L2 antibody
Short Description
Description Rabbit polyclonal to CREB3L2.
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-CREB3L2 antibody
Immunogen Synthesized peptide derived from human CREB3L2
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 58 kDa
Database Links
Alternative Names Cyclic AMP-responsive element-binding protein 3-like protein 2 antibody
cAMP-responsive element-binding protein 3-like protein 2 antibody
BBF2 human homolog on chromosome 7 antibody
Processed cyclic AMP-responsive element-binding protein 3-like protein 2 antibody
BBF2H7 antibody
Function Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes . In a neuroblastoma cell line, protects cells from ER stress-induced death . In vitro activates transcription of target genes via direct binding to the CRE site .
Cellular Localization Endoplasmic reticulum membrane Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus. Upon ER stress, translocated into the nucleus.
Tissue Specificity Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
Swiss-Prot Key

 

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