Anti-CREBBP Antibody

Rs. 45,619.00
SKU stj29848

General Information

Product name Anti-CREBBP Antibody
Short Description Rabbit polyclonal to CREBBP
Description This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-CREBBP Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CREBBP (NP_004371.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 265.4 kDa
Database Links
Alternative Names CREBBPCREB-binding protein CREBBP antibodyCBP
Function Acetylates histones, giving a specific tag for transcriptional activation, Also acetylates non-histone proteins, like NCOA3 and FOXO1, Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes, Acts as a coactivator of ALX1, Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers, Acetylates PCNA
Cellular Localization Cytoplasm, Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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