Anti-CREM Antibody

Rs. 45,619.00
SKU stj27591

General Information

Product name Anti-CREM Antibody
Short Description Rabbit polyclonal to CREM
Description This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-CREM Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37 kDa
Database Links
Alternative Names CREMcAMP-responsive element modulator antibodyInducible cAMP early repressor antibodyICERCREM
Function Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters, Isoforms are either transcriptional activators or repressors, Plays a role in spermatogenesis and is involved in spermatid maturation.
Cellular Localization Nucleus
Tissue Specificity Expressed in testes (round spermatids) (at protein level), isoform 14 is the major activator form in testes.
Swiss-Prot Key

 

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