Anti-CRK Antibody

Rs. 57,098.00
SKU stj29821

General Information

Product name Anti-CRK Antibody
Short Description Rabbit polyclonal to CRK
Description This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Applications WB,ICC,IP,FC
Dilution range WB 1:500 - 1:2000
ICC 1:50 - 1:100
IP 1:50 - 1:100
FC 1:50 - 1:200
Protein Name Anti-CRK Antibody
Immunogen Recombinant protein of human CRK
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.8 kDa
Database Links
Alternative Names CRKAdapter molecule crk antibodyProto-oncogene c-Crk antibodyp38CRK
Function Isoform Crk-II: Regulates cell adhesion, spreading and migration, Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner, Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4, May regulate the EFNA5-EPHA3 signaling.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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