Anti-CRYAB Antibody

Rs. 45,619.00
SKU stj115651

General Information

Product name Anti-CRYAB Antibody
Short Description Rabbit polyclonal to CRYAB
Description Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Alpha-crystallin B chainAlpha(B-crystallinHeat shock protein beta-5HspB5Renal carcinoma antigen NY-REN-27Rosenthal fiber component
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human CRYAB (NP_001876.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 20.2 kDa
Database Links
Alternative Names CRYABAlpha-crystallin B chain antibodyAlpha(B antibody-crystallin antibodyHeat shock protein beta-5 antibodyHspB5 antibodyRenal carcinoma antigen NY-REN-27 antibodyRosenthal fiber componentCRYAB antibodyCRYA2 antibodyHSPB5
Function May contribute to the transparency and refractive index of the lens, Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions
Cellular Localization Cytoplasm.
Tissue Specificity Lens as well as other tissues.
Swiss-Prot Key

 

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