Anti-CSN1 antibody

Rs. 50,211.00
SKU stj92498

General Information

Product name Anti-CSN1 antibody
Short Description
Description Rabbit polyclonal to CSN1.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-CSN1 antibody
Immunogen Synthesized peptide derived from human CSN1 around the non-phosphorylation site of S454.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 53.372 kDa
Database Links
Alternative Names COP9 signalosome complex subunit 1 antibody
SGN1 antibody
Signalosome subunit 1 antibody
G protein pathway suppressor 1 antibody
GPS-1 antibody
JAB1-containing signalosome subunit 1 antibody
Protein MFH antibody
COPS1 antibody
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Cellular Localization Cytoplasm Nucleus
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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