Anti-CSNK1D Antibody

Rs. 68,577.00
SKU stj70916

General Information

Product name Anti-CSNK1D Antibody
Short Description Goat polyclonal to CSNK1D
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-CSNK1D Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 47.3 kDa
Database Links
Alternative Names CSNK1DCasein kinase I isoform delta antibodyCKI-delta antibodyCKIdCSNK1D antibodyHCKID
Function Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms, It can phosphorylate a large number of proteins, Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates, Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2, Central component of the circadian clock, In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation, Controls PER1 and PER2 nuclear transport and degradation, YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation, DNMT1 phosphorylation reduces its DNA-binding activity, Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation, Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth, EIF6 phosphorylation promotes its nuclear export, Triggers down-regulation of dopamine receptors in the forebrain, Activates DCK in vitro by phosphorylation, TOP2A phosphorylation favors DNA cleavable complex formation, May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast, Modulates connexin-43/GJA1 gap junction assembly by phosphorylation, Probably involved in lymphocyte physiology, Regulates fast synaptic transmission mediated by glutamate,
Cellular Localization Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, perinuclear region, Cell membrane, Cytoplasm, cytoskeleton, spindle, Golgi apparatus,
Tissue Specificity Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle, however, kinase activity is not uniform, with highest kinase activity in splenocytes, in blood, highly expressed in hemopoietic cells and mature granulocytes, also found in monocytes and lymphocytes,
Swiss-Prot Key

 

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