Anti-CSNK2A2 Antibody

Rs. 45,619.00
SKU stj115442

General Information

Product name Anti-CSNK2A2 Antibody
Short Description Rabbit polyclonal to CSNK2A2
Description
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Casein kinase II subunit alpha'CK II alpha'
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CSNK2A2 (NP_001887.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 41.2 kDa
Database Links
Alternative Names CSNK2A2Casein kinase II subunit alpha' antibodyCK II alpha'CSNK2A2 antibodyCK2A2
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine, Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection, May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response, During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage, Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation, Can also negatively regulate apoptosis, Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3, Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8, Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV, Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB, Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function, Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1, Acts as an ectokinase that phosphorylates several extracellular proteins, During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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