Anti-CSPG4 Antibody

Rs. 45,619.00
SKU stj29905

General Information

Product name Anti-CSPG4 Antibody
Short Description Rabbit polyclonal to CSPG4
Description A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CSPG4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1950-2210 of human CSPG4 (NP_001888.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 250.5 kDa
Database Links
Alternative Names CSPG4Chondroitin sulfate proteoglycan 4 antibodyChondroitin sulfate proteoglycan NG2 antibodyMelanoma chondroitin sulfate proteoglycan antibodyMelanoma-associated chondroitin sulfate proteoglycanCSPG4 antibodyMCSP
Function Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis, May also inhibit neurite outgrowth and growth cone collapse during axon regeneration, Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate, Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity, May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties, May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin, Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins, May promote retraction fiber formation and cell polarization through Rho GTPase activation, May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1, May activate FAK and ERK1/ERK2 signaling cascades.
Cellular Localization Cell membrane.
Tissue Specificity Detected only in malignant melanoma cells.
Swiss-Prot Key

 

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