Anti-CSRP3 Antibody

Rs. 45,619.00
SKU stj115335

General Information

Product name Anti-CSRP3 Antibody
Short Description Rabbit polyclonal to CSRP3
Description This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
Applications IF
Dilution range IF 1:50 - 1:200
Protein Name Cysteine and glycine-rich protein 3Cardiac LIM proteinCysteine-rich protein 3CRP3LIM domain proteincardiacMuscle LIM protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human CSRP3 (NP_003467.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 21 kDa
Database Links
Alternative Names CSRP3Cysteine and glycine-rich protein 3 antibodyCardiac LIM protein antibodyCysteine-rich protein 3 antibodyCRP3 antibodyLIM domain protein antibodycardiac antibodyMuscle LIM proteinCSRP3 antibodyCLP antibodyMLP
Function Positive regulator of myogenesis, Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6, Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity), Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes, Could play a role in mechanical stretch sensing, May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures, It is essential for calcineurin anchorage to the Z line, Required for stress-induced calcineurin-NFAT activation (By similarity), The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization.
Cellular Localization Nucleus.
Tissue Specificity Cardiac and slow-twitch skeletal muscles, isoform 2 is expressed in striated muscle, isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2a (lgmd2a), duchenne muscular dystrophy (dmd) and dermatomyositis.
Swiss-Prot Key

 

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