Anti-CTCFL Antibody

Rs. 45,619.00
SKU stj27902

General Information

Product name Anti-CTCFL Antibody
Short Description Rabbit polyclonal to CTCFL
Description CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:20 - 1:100
Protein Name Anti-CTCFL Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CTCFL (NP_001255970.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 75.7 kDa
Database Links
Alternative Names CTCFLTranscriptional repressor CTCFL antibodyBrother of the regulator of imprinted sites antibodyCCCTC-binding factor antibodyCTCF paralog antibodyCTCF-like protein antibodyCancer/testis antigen 27 antibodyCT27 antibodyZinc finger protein CTCF-TCTCFL antibodyBORIS
Function Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers, Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR), Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2, This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity), Seems to act as tumor suppressor, In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter, Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Testis specific, specifically expressed in primary spermatocytes
Swiss-Prot Key

 

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