Anti-CtIP antibody

Rs. 50,211.00
SKU stj92516

General Information

Product name Anti-CtIP antibody
Short Description
Description Rabbit polyclonal to CtIP.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-CtIP antibody
Immunogen Synthesized peptide derived from human CtIP around the non-phosphorylation site of S664.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 100 kDa
Database Links
Alternative Names DNA endonuclease RBBP8 antibody
CtBP-interacting protein antibody
Retinoblastoma-binding protein 8 antibody
RBBP-8 antibody
Retinoblastoma-interacting protein and myosin-like antibody
RIM antibody
Sporulation in the absence of SPO11 protein 2 homolog antibody
SAE2 antibody
CTIP antibody
Function Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage . During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations .
Cellular Localization Nucleus Chromosome. Associates with sites of DNA damage in S/G2 phase . Ubiquitinated RBBP8 binds to chromatin following DNA damage .
Tissue Specificity Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level).
Swiss-Prot Key

 

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