Anti-CTLA4 Antibody

Rs. 45,619.00
SKU stj23265

General Information

Product name Anti-CTLA4 Antibody
Short Description Rabbit polyclonal to CTLA4
Description This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CTLA4 Antibody
Immunogen Recombinant protein of human CTLA4
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 24.7 kDa
Database Links
Alternative Names CTLA4Cytotoxic T-lymphocyte protein 4 antibodyCytotoxic T-lymphocyte-associated antigen 4 antibodyCTLA-4 antibodyCD antigen CD152CTLA4 antibodyCD152
Function Inhibitory receptor acting as a major negative regulator of T-cell responses, The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Cellular Localization Cell membrane.
Tissue Specificity Widely expressed with highest levels in lymphoid tissues, detected in activated t-cells where expression levels are 30- to 50-fold less than cd28, the stimulatory coreceptor, on the cell surface following activation.
Swiss-Prot Key

 

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