Anti-CTNNA1 Antibody

Rs. 45,619.00
SKU stj27602

General Information

Product name Anti-CTNNA1 Antibody
Short Description Rabbit polyclonal to CTNNA1
Description This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Applications WB,IHC,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-CTNNA1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 637-906 of human CTNNA1 (NP_001894.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 100.1 kDa
Database Links
Alternative Names CTNNA1Catenin alpha-1 antibodyAlpha E-catenin antibodyCadherin-associated protein antibodyRenal carcinoma antigen NY-REN-13CTNNA1
Function Associates with the cytoplasmic domain of a variety of cadherins, The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties, Can associate with both E- and N-cadherins, Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions, In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components, The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments, May play a crucial role in cell differentiation.
Cellular Localization Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell membrane
Tissue Specificity Expressed ubiquitously in normal tissues
Swiss-Prot Key

 

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