Anti-CTNNA1 Antibody

Rs. 68,577.00
SKU stj70919

General Information

Product name Anti-CTNNA1 Antibody
Short Description Goat polyclonal to CTNNA1
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-CTNNA1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 100.1 kDa
Database Links
Alternative Names CTNNA1Catenin alpha-1 antibodyAlpha E-catenin antibodyCadherin-associated protein antibodyRenal carcinoma antigen NY-REN-13CTNNA1
Function Associates with the cytoplasmic domain of a variety of cadherins, The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties, Can associate with both E- and N-cadherins, Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions, In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components, The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments, May play a crucial role in cell differentiation,
Cellular Localization Cytoplasm, cytoskeleton, Cell junction, adherens junction, Cell membrane
Tissue Specificity Expressed ubiquitously in normal tissues
Swiss-Prot Key

 

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