Anti-CTNNB1 Antibody

Rs. 45,619.00
SKU stj23270

General Information

Product name Anti-CTNNB1 Antibody
Short Description Rabbit polyclonal to CTNNB1
Description The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-CTNNB1 Antibody
Immunogen A synthetic peptide of human CTNNB1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 85.5 kDa
Database Links
Alternative Names CTNNB1Catenin beta-1 antibodyBeta-cateninCTNNB1 antibodyCTNNB antibodyOK/SW-cl.35 antibodyPRO2286
Function Key downstream component of the canonical Wnt signaling pathway, In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome, In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes, Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex, Acts as a negative regulator of centrosome cohesion, Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization, Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2, Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths, expressed in colon, present in cortical neurons (at protein level), expressed in breast cancer tissues (at protein level).
Swiss-Prot Key

 

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