Anti-CTNS Antibody

Rs. 45,619.00
SKU stj28973

General Information

Product name Anti-CTNS Antibody
Short Description Rabbit polyclonal to CTNS
Description This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-CTNS Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CTNS (NP_001026851.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 41.7 kDa
Database Links
Alternative Names CTNSCystinosinCTNS
Function Cystine/H(+) symporter thought to transport cystine out of lysosomes, Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.
Cellular Localization Lysosome membrane
Tissue Specificity Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes, expressed at lower levels in placenta and heart, weakly expressed in lung, liver and brain (adult and fetal), isoform 2 represents 5-20 % of ctns transcripts, with the exception of the testis that expresses both isoforms in equal proportions.
Swiss-Prot Key

 

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