Anti-CUL4B Antibody

Rs. 45,619.00
SKU stj27353

General Information

Product name Anti-CUL4B Antibody
Short Description Rabbit polyclonal to CUL4B
Description This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-CUL4B Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CUL4B (NP_003579.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 104 kDa
Database Links
Alternative Names CUL4BCullin-4B antibodyCUL-4BCUL4B antibodyKIAA0695
Function Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit, CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage, Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication, Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression, Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism, Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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